67. Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma.
Duraj T, Kalamian M, Zuccoli G, Marron JC, D’Agostino DP, Scheck AC, Poff A, Winter SF, Hu J, Klement RJ, …, Seyfried TN BMC Medicine. 2024 Dec; accepted
66. Anti-cancer effects of hyperbaric oxygen therapy in mice: A meta-analysis.
Klement RJ, Eckert JM, Sweeney RA. Oncologie. 2024 Aug; published ahead of print
65. Feasibility and metabolic effects of a 5:2 fasting intervention in women with breast cancer during radiotherapy.
Klement RJ, Figueroa J, Weigel M, Champ CE, Ok S, Sweeney RA. Holistic Integrative Oncology. 2023 Oct; 2:35
64. Anti-tumor effects of ketogenic diets and their synergism with other treatments in mice: Bayesian evidence synthesis of 1755 individual mouse survival data.
Klement RJ. Biomedical Journal. 2024 Feb; 47(1):100609
63. RT-qPCR test targeting the conserved 5´-UTR of SARS-CoV-2 overcomes major shortcomings of the first WHO-recommended RT-qPCR test
Kämmerer U, Pekova S, Klement RJ, Louwen R, Borger P, Steger K. International Journal of Vaccine Theory, Practice, and Research. 2023 Apr; 3(1):818–846
62. Measurement of body composition by DXA, BIA, Leg-to-leg BIA and near-infrared spectroscopy in breast cancer patients – Comparison of the four methods.
Klement RJ, Joos FT, Reuss-Borst MA, Kämmerer U. Clinical Nutrition ESPEN 2023 Mar; 54:443-452
61. SEIR models in the light of Critical Realism – a critique of exaggerated claims about the effectiveness of Covid 19 vaccinations
Klement RJ, Walach H Futures 2023 Apr; 148:103119
60. Effects of Viktor Philippi’s Bioenergetic Meditation on anxiety, burnout and depression: an analysis of four feasibility studies
Lehnert W, Günther-Pusch J, Klement RJ. Complementary Medicine Research. 2023; 30(2):130-140
59. Was there a need for high carbohydrate content in Neanderthal diets?
Klement RJ. American Journal of Biological Anthropology. 2022 Dec; 179(4):668-677
58. Is the Network of World Economic Forum Young Global Leaders Associated with COVID-19 Non-Pharmaceutical Intervention Severity?
Klement RJ, Walach H. Cureus. 2022 Oct; 14(10): e29990
57. Effect of Ketogenic Diets on Cardio-Metabolic Outcomes in Cancer Patients: A Systematic Review and Meta-Analysis of Controlled Clinical Trials
Amanollahi A, Khazdouz M, Malekahmadi M, Klement RJ, Lee D, Khodabakhshi A. Nutrition and Cancer. 2022 Sep [online ahead of print]
56. Why do people consent to receiving SARS-CoV2 vaccinations? A Representative Survey in Germany
Walach H, Ofner M, Ruof V, Herbig M, Klement RJ. BMJ Open. 2022 Aug; 12:e060555
55. Identifying factors associated with Covid-19 related deaths during the first wave of the pandemic in Europe
Klement RJ, Walach H. Frontiers in Public Health. 2022 July; 10:922230
54. Impact of a ketogenic diet intervention during radiotherapy on body composition: V. Final results of the KETOCOMP study for head and neck cancer patients
Klement RJ, Sweeney RA. Strahlentherapie und Onkologie. 2022 May; Download: KETOCOMP Paper V.
53. Bayes Lines Tool (BLT) – A SQL-script for analyzing diagnostic test results with an application to SARS-CoV-2-testing [version 3; peer review: 2 approved]
Aukema W, Kämmerer U, Borger P, Goddek S, Malhotra BJ, McKernan K, Klement RJ. F1000 Research 2022 Mar; 10:369
52. Ketogenic diets consumed during radio-chemotherapy have beneficial effects on quality of life and metabolic health in patients with rectal cancer.
Klement RJ, Meyer D, Kanzler S, Sweeney RA. European Journal of Nutrition 2022 Feb; 61(1):69-84 Download here
51. Accelerated Hyper- versus Normofractionated Radiochemotherapy with Temozolomide in Patients with Glioblastoma: A Multicenter Retrospective Analysis.
Klement RJ, Popp I, Kaul D, Ehret F, Grosu AL, Polat B, Sweeney RA, Lewitzki V. Journal of Neuro-Oncology. 2022 Jan; 156:407–417
50. The Safety of Covid-19 Vaccinations – Should We Rethink the Policy? (newly and independently peer-reviewed version)
Walach H, Klement RJ, Aukema W. Science, Public Health Policy & the Law. 2021 Aug; 3:87-99
49. The Safety of Covid-19 Vaccinations – We should Rethink the Policy (Retracted)
Walach H, Klement RJ, Aukema W. Vaccines 2021 Jun; 9(7):693. This paper has been retracted for political reasons, after several editors (all with conflicts of interest biased towards vaccine propagation) have resigned from their editorial position or threatened to do so. Prof. Harald Walach and me wrote a reponse to the retraction that the journal however did not publish. You can download our response here.
48. Impact of a ketogenic diet intervention during radiotherapy on body composition: IV. Final results of the KETOCOMP study for rectal cancer patients.
Klement RJ, Koebrunner PS, Meyer D, Kanzler S, Sweeney RA. Clinical Nutrition 2021 June; DOI: 10.1016/j.clnu.2021.05.015
47. Low Carb and ketogenic diets increase quality of life, physical
performance, body composition and metabolic health of women with breast cancer better than a standard diet.
Kämmerer U, Klement RJ, Joos FT. Sütterlin M, Reuss-Borst M. Nutrients. 2021 Mar; 13(3):1029
46. Stereotactic or conformal radiotherapy for adrenal metastases – patient characteristics and outcomes in a multicenter analysis.
Buergy D, Wuerschmidt F, Gkika E, Hörner-Rieber J, Knippen S, Gerum S, Balermpas P, Henkenberens C, Voglhuber T, Kornhuber C, Barczyk S, Roeper B, Rashid A, Blanck O, Wittig A, Herold H-U, Brunner T, Klement RJ, Kahl KH, Ciernik I, Ottinger A, Izaguirre V, Putz F, Koenig L, Hoffmann M, Combs AE, Guckenberger M, Boda-Heggemann J. International Journal of Cancer (accepted, 2021)
45. High-dose re-irradiation of intracranial lesions – Efficacy and safety including dosimetric analysis based on accumulated EQD2Gy dose EQD calculation.
Stiefel I, Schröder C, Tanadini-Lang S, Pytko I, Klement RJ, Guckenberger M, Andratschke N. Clinical and Translational Radiation Oncology 2021 Mar; 27:132-138
44. A ketogenic diet consumed during radiotherapy improves several aspects of quality of life and metabolic health in women with breast cancer.
Klement RJ, Weigel MM, Sweeney RA. Clinical Nutrition 2021 Jun; 40(6):4267-4274.
43. Short-term effects of a Paleolithic lifestyle intervention in breast cancer patients undergoing radiotherapy: A pilot and feasibility study.
Klement RJ, Koebrunner PS, Krage K, Weigel MM, Sweeney RA. Medical Oncology. 2021 Jan; 38(1):1
42. Low vitamin D status in a cancer patient population from Franconia, Germany.
Klement RJ, Koebrunner PS, Krage K, Sweeney RA. Complementary Medicine Research. 2020 Dec; Download:
41. The epistemology of a positive SARS-CoV-2 test.
Klement RJ, Bandyopadhyay PS. Acta Biotheoretica. 2020 Sept; (in press)
40. Impact of a ketogenic diet intervention during radiotherapy on body composition: III—final results of the KETOCOMP study for breast cancer patients.
Klement RJ, Champ CE, Kämmerer U, Koebrunner PS, Krage K, Schäfer G, Weigel M, Sweeney RA. Breast Cancer Research. 2020 Aug; 22:94
39. A ketogenic diet exerts beneficial effects on body composition of cancer patients during radiotherapy: An interim analysis of the KETOCOMP study.
Klement RJ, Schäfer G, Sweeney RA. Journal of Traditional and Complementary Medicine. 2020 May; 10(3):180-187
38. Correlating dose variables with local tumor control in stereotactic body radiotherapy for early stage non-small cell lung cancer: A modelling study on 1500 individual treatments.
Klement RJ, Sonke J-J, Allgäuer M, Andratschke N, Appold S, Belderbos J, Belka C, Blanck O, Diekmann K, Eich HT, Mantel F, Eble M, Hope A, Grosu AJ, Nevinny-Stickel M, Semrau S, Sweeney RA, Hörner-Rieber J, Werner-Wasik M, Engenhart-Cabiliic R, Ye H, Grills I, Guckenberger M. International Journal of Radiation Oncology*Biology*Physics. 2020 Jul; 107(3):579-586. Download here
37. Assessing Successful Completion of Calorie Restriction Studies for the Prevention and Treatment of Cancer.
Champ CE, Klement RJ. Nutrition. 2020 May; 78:110829. Download here
36. Estimation of the α/β ratio of non-small cell lung cancer treated with stereotactic body radiotherapy.
Klement RJ, Sonke J-J, Allgäuer M, Andratschke N, Appold S, Belderbos J, Belka C, Diekmann K, Eich HT, Flentje M, Grills I, Eble M, Hope A, Grosu AJ, Semrau S, Sweeney RA, Hörner-Rieber J, Werner-Wasik M, Engenhart-Cabiliic R, Ye H, Guckenberger M. Radiotherapy & Oncology. 2020 Jan; 142(1):210-216. Download here
35. Accelerated hyperfractionated radiochemotherapy with temozolomide is equivalent to normofractionated radiochemotherapy in a retrospective analysis of patients with glioblastoma.
Lewitzki V, Klement RJ, Kosmala R, Lisowski D, Flentje M, Polar B. Radiation Oncology. 2019 Dec; 14: 227.
34. Risk factors for vertebral compression fracture after spine stereotactic body radiation therapy: long-term results of a prospective phase 2 study.
Mantel F, Sweeney RA, Klement RJ, Hawkins MA, Belderbos J, Ahmed M, Toussaint A, Polat B, Flentje M, Guckenberger M. Radiotherapy & Oncology. 2019 Dec; 141(12): 62-66.
33. Emergence and evidence: A close look at Bunge’s philosophy of medicine.
Klement RJ, Bandyopadhyay PS. Philosophies. 2019 Aug; 4(3):50
32. The Impact of Serum Glucose in the Treatment of Locoregionally Advanced Pancreatic Cancer.
Iarrobino N, Gill B, Klement RJ, Bernard M, Champ CE. American Journal of Clinical Oncology. 2019 Sept; 42(9):692-697. Download here
31. External validation of a prognostic score for patients with brain metastases based on extracranial factors.
Lewitzki V, Klement RJ, Hess S, Kosmala R, Nieder C, Flenje M. Clinical and Translational Radiation Oncology. 2019 May; 16:15-20
30. The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases.
Klement RJ, Abbasi-Senger N, Adebahr S, Alheid H, Allgaeuer M, Becker G, Blanck O, Boda-Heggemann J, Brunner T, Duma M, Eble MJ, Ernst I, Gerum S, Habermehl D, Hass P, Henkenberens C, Hildebrandt G, Imhoff D, Kahl H, Klass ND, Krempien R, Lewitzki V, Lohaus F, Ostheimer C, Papachristofilou A, Petersen C, Rieber J, Schneider T, Schrade E, Semrau S, Wachter S, Wittig A, Guckenberger M, Andratschke N. BMC Cancer. 2019 Feb; 19:173
29. Application of Bayesian evidence synthesis to modelling the effect of ketogenic therapy on survival of high grade glioma patients.
Klement RJ, Bandyopadhyay PS, Champ CE, Walach H. Theoretical Biology and Medical Modelling. 2018 Aug; 15:12
28. The impact of serum glucose, anti-diabetic agents, and statin usage in non-small cell lung cancer patients treated with definitive chemoradiation.
Iarrobino NA, Gill BS, Bernard M, Klement RJ, Werner-Wasik M, Champ CE. Frontiers in Oncology. 2018 Jul; 8:281.
27. Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation.
Bartmann C, Raman SJ, Flöter J, Schulze A, Bahlke K, Willingstorfer J, Strunz M, Wöckel A, Klement RJ, Kapp M, Djuzenova C, Otto C, Kämmerer U. Cancer & Metabolism. 2018 Jun; 6:8. Download here
25. Stereotactic Body Radiotherapy (SBRT) for Multiple Pulmonary Oligometastases: Analysis of Number and Timing of Repeat SBRT as Impact Factors on Treatment Safety and Efficacy.
Klement RJ, Hörner-Rieber J, Adebahr S, Andratschke N, Blanck O, Boda-Heggemann J, Duma NM, Eble MJ, Eich HT, Flentje M, Gerum S, Hass P, Henkenberens C, Hildebrandt G, Imhoff D, Kahl KH, Klass ND, Krempien R, Lohaus F, Petersen C, Schrade E, Wendt TG, Wittig A, Guckenberger M. Radiotherapy & Oncology. 2018 Mar; 127(2):246-252.
24. Assessing Changes in the Activity Levels of Breast Cancer Patients during Radiation Therapy.
Champ CE, Ohri N, Klement RJ, Cantor M, Beriwal S, Glaser SM, Smith RP. Clinical Breast Cancer. 2018 Feb; 18(1):e1-e6. Download: Changes in the Activity Levels of Breast Cancer Patients
23. Radiobiological parameters of liver and lung metastases derived from tumor control data of 3719 metastases.
Klement RJ. Radiotherapy & Oncology. 2017 May; 123(2):218-226. Download: Radiobiological parameters of liver and lung metastases
22. Stereotactic body radiotherapy for oligo-metastatic liver disease – influence of pre-treatment chemotherapy and histology on local tumor control.
Klement RJ, Guckenberger M, Alheid H, Allgäuer M, Becker G, Blanck O, Boda-Heggemann J, Brunner T, Duma M, Gerum S, Habermehl D, Hildebrandt G, Lewitzki V, Ostheimer C, Papachristofilou A, Petersen C, Schneider T, Semrau R, Wachter S, Andratschke N. Radiotherapy & Oncology. 2017 May; 123(2): 227-233. Download: SBRT for Liver Metastases
21. Prediction of early death in patients with early stage NSCLC – can we select patients without a potential benefit of SBRT as a curative treatment approach?
Klement RJ, Belderbos J, Grills I, Werner-Wasik M, Hope A, Giuliani M, Ye H, Sonke J-J, Peulen H, Guckenberger M. Journal of Thoracic Oncology. 2016 July; 11(7): 1132-1139. Download: Prediction of Early Death in Patients with Stage I NSCLC
20. Anti-tumor effects of ketogenic diets in mice: A meta-analysis.
Klement RJ, Champ CE, Otto C, Kämmerer U. PLoS ONE. 2016 May; 11(5): e0155050
19. Bayesian cure rate modeling of local tumor control: Evaluation in stereotactic body radiotherapy for pulmonary metastases.
Klement RJ, Allgäuer M, Andratschke N, Blanck O, Boda-Heggemann J, Dieckmann K, Duma M, Ernst I, Flentje M, Ganswindt U, Hass P, Henkenberens C, Imhoff D, Kahl HK, Krempien R, Lohaus F, Nestle U, Nevinny-Stickel M, Petersen C, Schmitt V, Semrau S, Streblow J, Wendt TG, Wittig A, Sterzing F, Guckenberger M. International Journal of Radiation Oncology*Biology*Physics. 2016 Mar; 94(4):841-849.
18. Local tumor control probability modeling of primary and secondary lung tumors in stereotactic body radiotherapy.
Guckenberger M, Klement RJ, Allgäuer M, Andratschke N, Blanck O, Boda-Heggemann J, Dieckmann K, Duma M, Ernst I, Flentje M, Ganswindt U, Hass P, Henkenberens C, Imhoff D, Kahl HK, Krempien R, Lohaus F, Nestle U, Nevinny-Stickel M, Petersen C, Semrau S, Streblow J, Wendt TG, Wittig A, Flentje M, Sterzing F. Radiotherapy & Oncology. 2016 Mar; 118(3):485-491
17. TKTL-1 expression of human malign and benign cell lines.
Kämmerer U, Gires O, Pfetzer N, Wiegering A, Klement RJ, Otto C. BMC Cancer. 2015 Jun; 15: 2
16. Support vector machine-based prediction of local tumor control after stereotactic body radiation therapy for early-stage non-small cell lung cancer.
Klement RJ, Allgäuer M, Appold S, Dieckmann K, Ernst I, Ganswindt U, Holy R, Nestle U, Nevinny-Stickel M, Semrau S, Sterzing F, Wittig A, Andratschke N, Guckenberger M. International Journal of Radiation Oncology*Biology*Physics. 2014 Mar; 88 (3): 732-738. Download: SVM_based_TCP_prediction_Author Copy
15. Applicability of the linear-quadratic formalism for modeling local tumor control probability in high dose per fraction stereotactic body radiotherapy for early stage non-small cell lung cancer.
Guckenberger M, Klement RJ, Allgäuer M, Appold S, Dieckmann K, Ernst I, Ganswindt U, Holy R, Nestle U, Nevinny-Stickel M, Semrau S, Sterzing F, Wittig A, Andratschke N, Flentje M. Radiotherapy & Oncology. 2013 Oct; 109 (1): 13-20
14. Reanalysis of the FEROS observations of HIP 11952.
Müller A, Roccatagliata V, Henning Th, Fedele D, Pasquali A, Caffau E, Rodríguez-Ledesma MV, Mohler-Fischer M, Seemann U, Klement RJ. Astronomy & Astrophysics. 2013 Aug; 556:A3, 7 pp
13. A pilot case study on the impact of a self-prescribed ketogenic diet on biochemical Parameters and running Performance in healthy and physically active individuals.
Klement RJ, Frobel T, Albers T, Fikenzer S, Prinzhausen J, Kämmerer U. Nutrition and Medicine. 2011 Jul; 1(1):10
12. Lack of a dose-effect relationship for pulmonary function changes after stereotactic body radiation therapy for early-stage non-small cell lung cancer.
Guckenberger M, Klement RJ, Kestin LL, Hope AJ, Belderbos J, Werner-Wasik M, Yan D, Sonke JJ, Bissonnette JP, Xiao Y, Grills IS. International Journal of Radiation Oncology*Biology*Physics. 2013 Mar; 85(4):1074-1081
11. Planetary companions around the metal-poor star HIP 11952.
Setiawan J, Roccatagliata V, Fedele D, Henning Th, Pasquali A, Rodríguez-Ledesma MV, Caffau E, Seemann U, Klement RJ. Astronomy & Astrophysics. 2012 Apr; 540:A141
10. The Photometric Classification Server for Pan-STARRS1.
Saglia RP, Tonry JL, Bender R, Greisel N, Seitz S, Senger R, Snigula J, Phleps S, Wilman D, Bailer-Jones CAL, Klement RJ, Rix H-W, Smith K, Green PJ, Burgett WS, Chambers KC, Heasley JN, Kaiser N, Magnier EA, Morgan JS, Price PA, Stubbs CW, Wainscoat RJ. The Astrophysical Journal. 2012 Feb; 746(2):ID 128
9. Kinematics of stellar populations with RAVE data.
Karataş Y, Klement RJ. New Astronomy. 2012 Jan; 17(1):22-33. Download: Karatas_Klement_2012_authorCopy
8. Classification of Field Dwarfs and Giants in RAVE and Its Use in Stellar Stream Detection.
Klement RJ, Bailer-Jones CAL, Fuchs B, Rix H-W, Smith KW. The Astrophysical Journal. 2011 Jan; 726(2):ID 103
7. A Giant Planet Around a Metal-Poor Star of Extragalactic Origin.
Setiawan J, Klement RJ, Henning T, Rix H-W, Rochau B, Rodmann J, Schulze-Hartung T. Science. 2010 Dec; 330(6011):1642-1644
6. Observational Evidence from SDSS for a Merger Origin of the Milky Way’s Thick Disk.
Dierickx M, Klement R, Rix H-W, Liu C. The Astrophysical Journal Letters. 2010 Dec; 725(2):L186-L190
5. Photometric identification of blue horizontal branch stars.
Smith KW, Bailer-Jones CAL, Klement RJ, Xue XX. Astronomy & Astrophysics. 2010 Nov; 522:A88
4. Halo Streams in the Seventh Sloan Digital Sky Survey Data Release.
Klement R, Rix H-W, Flynn C, Fuchs B, Beers TC, Allende Prieto C, Bizyaev D, Brewington H, Lee YS, Malanushenko E, Malanushenko V, Oravetz D, Pan K, Re Fiorentin P, Simmons A, Snedden S. The Astrophysical Journal. 2009 June; 698(1):865-894
3. The Kinematics of Late-Type Stars in the Solar Cylinder Studied with SDSS Data.
Fuchs B, Dettbarn C, Rix H-W, Beers TC, Bizyaev D, Brewington H, Jahreiß H, Klement R, Malanushenko E, Malanushenko V, Oravetz D, Pan K, Simmons A, Snedden S. The Astronomical Journal. 2009 May; 137 (5): 4149-4159
2. Identifying Stellar Streams in the First RAVE Public Data Release.
Klement R, Fuchs B, Rix H-W. The Astrophysical Journal. 2008 Sept; 685: 261-271
1. Contamination by field late-M, L, and T dwarfs in deep surveys.
Caballero JA, Burgasser AJ, Klement R. Astronomy & Astrophysics. 2008 Sept; 488(1): 181-190
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