Observations that caloric restriction, i.e. a reduction in total energy intake from what would usually be consumed (called ad libitum intake), retards tumor growth in experimental animals have been published as early as 1909 by C. Moreschi [1]. In recent years, calorie restriction has been more systematically investigated, usually as a 20-40% proportional reduction of energy intake from ad libitum feeding. It has been found that it not only retards tumor growth but could also sensitize tumor cells to pro-oxidative therapies such as ionizing radiation and chemotherapeutics. The big question is through which mechanism(s)? Weiterlesen →